ARIZE®

IMPORTANT NOTICE: Breastfeeding is best for infants and is recommended for as long as possible during infancy. Arize is a food for special medical uses for infants and should be used under medical supervision.


Arize, by Similac, is the first and only hydrolysed rice protein iFSMP* available in the UK and contains synthesised 2’-fucosyllactose (2’-FL†) human milk oligosaccharide (HMO). Arize has been specially formulated for the dietary management of infants with cow’s milk protein allergy (CMPA) or other conditions where an extensively hydrolysed formula is clinically indicated.

Breast milk is the gold standard providing not only nutrition, but protection and support for the developing immune system.1-3 However, not every infant with allergies can be breastfed and a number of families depend on hypoallergenic formula.

Hydrolysed rice formulas (HRFs) are an established option for managing CMPA4-6 and have been recommended as a first line option by DRACMA and ESPGHAN guidelines for over 10 years.7,8

HRFs are shown to be nutritionally adequate and well tolerated in the dietary management of infants with CMPA:9,10

  • Proven hypoallergenicity and efficacy9-11
  • Supporting growth9,10
  • Palatability and cost-effectiveness9,11

Arize is designed to work first-line, 100% of the time in mild-to-moderate CMPA:12-14

  • 100% cow’s milk protein free
  • Nutritionally complete, supporting healthy growth5,15-18
  • Plant based‡ and suitable for vegetarians
  • Halal and Kosher certified
  • Containing 2’-FL and nucleotides to support infants’ developing immune systems19-21
  • 100% effective in eliminating symptoms of CMPA, in terms of hypoallergenicity.§12,13

Arize contains 2'-FL and nucleotides, which supports the immune system,19,22-23 and is fortified with lysine, threonine and tryptophan, bringing its amino acid composition closer to that of human milk than other HRFs.5

Arize has a high acceptance rate from as early as the first feed.24

Refer a Hcp Icon

ENTER A NEW ERA IN THE MANAGEMENT OF COW’S MILK PROTEIN ALLERGY 

Arize is a HRF, designed specifically to meet the nutritional needs of infants while managing CMPA and other conditions where an extensively hydrolysed formula (eHF) is clinically indicated.

 

Learn more about the benefits of HRFs in the management of CMPA and make an informed prescription choice that meets the highest standards for your patients’ health, growth and development.

Features

Suitable for 
Kosher diet
Suitable for
Halal diet
Suitable for
vegetarians
Clinically
lactose-free
Gluten free


¶ Maximum lactose content <68mg/L as fed, <10mg/100kcal

Nutrition

Arize is a Food for Special Medical Purposes for infants, for use under medical supervision.

Nutrition
Per 100 ml
Per 200 ml
Energy
287 kJ / 68 kcal631 kJ / 149 kcal
Protein

2.0 g

4.4 g

Preparation

  • Thoroughly wash and rinse all equipment to be used in preparing the feed. Sterilise all utensils according to manufacturers’ instructions or boil for 10 minutes.
  • Boil fresh tap water (not bottled water) and allow to cool for no more than 30 minutes. Do not use artificially softened water or repeatedly boiled water.
  • Wash your hands and clean the surface you are going to use.
  • Pour the correct amount of warm, previously boiled water into the sterilised feeding bottle.
  • Fill the scoop with Arize powder, levelling with the back of a clean, dry, knife. Do not pack down in scoop.
  • Add one scoop of Arize to each 30 ml of water. Only use the scoop provided. A level scoop contains 4.5 g powder.
  • Place lid on bottle and shake gently until completely dissolved.
  • Fit a sterilised teat on bottle and test the temperature (drops of formula should feel lukewarm on the inside of your wrist). If necessary, add cap and cool by holding under cold running water.
  • Discard prepared formula left in the bottle or cup within one hour after feeding begins.
  • We recommend preparing each feed as required. If you prepare more than one feed, it must be refrigerated at 2-4oC (35-40oF) and used within 24 hours.

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Footnotes:

DRACMA - Diagnosis and Rationale for Action against Cow's Milk Allergy
ESPGHAN - European Society for Paediatric Gastroenterology, Hepatology and Nutrition
*iFSMP - Food for special medical purposes for infants
†2’-FL - 2’-fucosyllactose. Structurally identical to that found in breast milk (not sourced from human milk).
‡Made from Extensively Hydrolysed Rice Protein.
§Resulted in zero reactions in two hypoallergenicity studies conducted in Risolac® now called Arize. Rice hydrolysate identical in both formulations.

References:

1. Kainonen E, et al. Immunological programming by breast milk creates an anti-inflammatory cytokine milieu in breast-fed infants compared to formula-fed infants. Brit J Nutrition 2013;109(11):1962–1970.
2. Walker A. Breast milk as the gold standard for protective nutrients. J Pediatr 2010;156(Suppl 2):S3–S7.
3. Lessen R, Kavanagh K. Position of the academy of nutrition and dietetics: promoting and supporting breastfeeding. J Acad Nutr Diet 2015;115(3):444–449.
4. Bocquet A, et al. Arch Pediatr. 2019;26(4):238–246. 
5. Dupont C, et al. Nutrients. 2020;12(9):E2654.
6. Helm RM, Burks AW. Cereal Foods World. 1996;41(11):839-843
7. Fiocchi A, et al. World Allergy Organ J. 2010;3(4):57-161
8. Koletzko S, et al. J Pediatr Gastroenterol Nutr. 2012;55(2):221–229
9. Fiocchi A, et al. World Allergy Organ J. 2022;15(12):100717.
10. Bejarano R, et al. JSM Nutr Disord. 2022;4(1):1011.
11. Anania C, et al. J Clin Med. 2022;11(16):4823.
12. Fiocchi A, et al. Clin Exp Allergy. 2003;33(11):1576–1580.
13. Fiocchi, A et al. Clin Exp Allergy. 2006;36(3):311–316.
14. Fiocchi A, et al. World Allergy Organ J. 2016;9(1):35.
15. Agostoni C, et al. Pediatr Allergy Immunol. 2007;18(7):599–606.
16. Reche M, et al. Pediatr Allergy Immunol. 2010;21(4 Pt 1):577–585.
17. Vandenplas Y, et al. Eur J Pediatr. 2014;173(9):1209–1216.
18. D’Auria E, et al. J Int Med Res. 2003;31(3):215–222.
19. Reverri EJ, et al. Nutrients. 2018;10(10):1346.
20. Merolla R, Sperimentatori GP. Minerva Pediatr. 2000;52(12):699–711.
21. Gutiérrez-Castrellón P, et al. Br J Nutr. 2007;98(Suppl 1):S64–S67.
22. Marriage BJ, et al. J Pediatr Gastroenterol Nutr. 2015;61(6):649–658.
23. Goehring KC, et al. J Nutr. 2016;146(12):2559–2566
24. Abbott. Data on File. Similac Arize. 2021.

 
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Order Date: 01/05/2024
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1,5 kcal / ml

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